Military Medical Expert Group: Be brave as a scientific and technological war “epidemic” commando
Group photo of a group of military medical experts fighting in Wuhan
January 2020,A sudden new crown pneumonia epidemic swept the country,The “pause button” was pressed in Wuhan, a thoroughfare of nine provinces.
This is a major public health emergency,It is also an unprecedented test.
Orders like a mountain,Charge forward.January 26,A team of military medical experts led by Chen Wei, a member of the Chinese Academy of Engineering and a researcher at the Academy of Military Medicine, was ordered to leave Wuhan.
In 113 days,All members of the expert group race against time, fight against illness, and compete with death,The first batch went out and the last batch was evacuated.
they,Not afraid of disease test samples,Reluctant to debug equipment day and night,Set up a benchmark for “scientific research fist”,The “Scientific Research Iron Army” brand was launched.
they,Implement the new military science spirit of “loyalty, research and warfare, innovation, truth-seeking, and sentiment” to the forefront of epidemic prevention and control.
they,Launch a series of major achievements with the best design, fastest speed and shortest time,Repay the commander’s trust and respond to people’s expectations with practical actions,Handed in an excellent answer to the “epidemic” of the science and technology war,Contributed military power to win the “Hubei Defense War and Wuhan Defense War”.
On March 16th, the expert group held a ceremony to join the party in the line of fire,Chen Wei takes the oath Photo by Shao Longfei
To Wuhan,Go to the front line of epidemic prevention and control,Go where the party and the people need it most!
January 25,The first day of the Chinese New Year.
at night,The phone of Zhang Xiaopeng, an associate researcher at the Academy of Military Medical Sciences rang–
“We are going to Wuhan to support,Can you hurry back?”
“no problem,Leave now!”
After receiving a call from Academician Chen Wei,Zhang Xiaopeng hurriedly bid farewell to his relatives.Half past one in the morning,He drove out of Shangqiu, Henan with his wife and daughter,Towards Beijing
at this time,After receiving the notice, Huang Yong, an assistant researcher who spent the New Year in his hometown in Sichuan,Immediately booked a ticket to Beijing that morning;
After the assistant researcher Chi Xiangyang, who had not returned to his hometown in Jilin for the New Year for ten years, accepted the task,Immediately cancelled the reserved ticket,Ask your lover to take care of the 3-year-old child;
Researchers Cao Cheng, Jiang Tao,Return to the laboratory for the first time to pack the box,Sort out more than 40 boxes of various equipment and reagents,It ensures that scientific research can be started as soon as possible after going out to the mission area.
In order to strengthen the front-line defense and control forces in Wuhan,Experts in the field of military medical research of the Academy of Military Sciences,Was ordered to form a military medical expert group,Responsible for emergency detection and scientific research on the Wuhan epidemic.
Academician Chen Wei served as the team leader,Researcher Cao Wuchun served as the deputy team leader.
This team of experts,They are the backbone forces engaged in pathogen research, vaccine research and development, and medical equipment research and development for a long time.From the SARS outbreak,To human infection with H7N9 avian influenza, and then to the 2014 West African Ebola pandemic,These years of tenacious battle with pathogens, these scientific research soldiers who have experienced many battles are once again in danger.
On the evening of January 26,The first group of 13 comrades boarded the plane,Head to Wuhan.
The epidemic is military situation,Prevention and control is responsibility.”Retrograde” is not a choice,It’s mission.
Researchers deployed equipment overnight at Huoshenshan Hospital. Shao Longfei Photo
Save people!Save people!
Do whatever is needed for epidemic prevention and control,Nucleic acid testing and antibody screening race against time!
After arriving in Wuhan,How to complete the missions and tasks assigned by superiors with high standards and quickly launch prevention and control is the most urgent and realistic issue facing the expert group.
at this time,The epidemic in Wuhan is on the rise,The city’s need for virus nucleic acid testing is very urgent.
The expert group held a party meeting overnight,The guiding ideology of “full chain design, integrated research, short-term and long-term consideration” was set,Clearly focus on vaccine research as the main focus,Testing traceability, expert guidance, sample collection, results verification, aerosol testing and other work were carried out simultaneously.
Prepare for the worst,Come up with the most adequate plan,Prepare to fight for the longest term!
Under the command of Academician Chen Wei,In just 24 hours,A negative pressure tent type mobile laboratory,It was built next to the pharmacy building of the General Hospital of the Central War Zone on the hillside.
The expert group built a fully automated nucleic acid extraction platform,Using self-developed kits,And the method of fully automatic nucleic acid extraction,The single-day specimen detection capacity can reach more than 1,000 samples.
Jiang Tao, leader of the nucleic acid detection group, said,At the beginning of the epidemic,Whether it is the detection speed,Or the proportion of tasks,Such responses are among the best in Wuhan.
In order to effectively detect the new coronavirus infection,In the first half of February,Associate researcher Zhang Xiaopeng of the expert group and his comrades began to build a fully automated antibody detection platform based on chemiluminescence.The platform can simultaneously detect the four antibodies of IgM and IgG of the N and S proteins of the new coronavirus.Improve the accuracy of patient clinical diagnosis.
Co-infection of new coronary pneumonia and other respiratory diseases,It is another major challenge facing clinical diagnosis and treatment.
to this end,The expert team has established a multiple pathogen detection platform,It can detect 16-22 kinds of respiratory pathogens such as influenza virus and Mycoplasma pneumonia at the same time,Effectively answered “Is it a new coronavirus infection?if not,What is the pathogenic infection” and other urgent clinical needs.
There were two critically ill patients,The hospital uses a variety of treatment options,The effect is not satisfactory.
After receiving the hospital’s demand,The expert group collected various body fluid samples of patients for comprehensive testing.The results show that,One of the patients is new coronary pneumonia combined with influenza B,Another patient had mycoplasma infection in his specimen.These tests have guided the clinical implementation of more targeted treatments.
“The expert group and related military and local units such as the Central Theater General Hospital,The working mechanism of joint defense, joint control, joint governance, and joint research was quickly established.Said Zhang Ke, an associate researcher in charge of scientific research management and task coordination of the expert group.In order to accelerate the progress of scientific research,The expert team set up a testing room in the infectious disease area of the hospital,Zero distance from clinical treatment,Real-time evaluation of treatment effects.
March 8,Academician Chen Wei checked the nucleic acid test data in the laboratory. Photo by Zhang Zhenwei
Rush up at critical moments, and overcome the crisis,Is the real communist
Prevention and treatment of new coronary pneumonia,It is very important to understand the law of transmission of the virus and its pathogenic mechanism.
In early February this year,The Wuhan epidemic has reached its peak.Whether the virus is spread through aerosols,Become a general concern.
Researcher Cao Cheng from the expert group led the team to Jinyintan Hospital for a full range of aerosol sampling.From office work area to material storage area,From the garbage disposal area to the inspection department,Even the ICU ward that treats critically ill patients,They were left everywhere.
In the ICU ward,The expert team members risked being infected,Next to the patient’s tracheal intubation operation,Collect air samples at zero distance.By collecting air samples from different environments in the hospital,Comprehensively assess the risk of infection within the hospital,Draw epidemiological survey results,Provide a scientific basis for clinical medical work.
Researchers Cao Wuchun and Cao Cheng, who are over fifty years old, have also led a team to go to Vulcan Mountain Hospital, Taikang Tongji Hospital and various cabin doctors to carry out multi-point and all-round aerosol propagation sampling investigations.It takes more than 6 hours to go in once.
once,Cao Wuchun was lying next to the public toilet of the Fangcai Hospital to sample the surface wipes.When the sampling is over,He took off his protective clothing and put on a military uniform,The nurses in the shelter hospital exclaimed: “Look, everyone,The sample just now is a general!”
“As an old party member,What’s the matter if it’s dirty or tired?”Cao Wuchun’s answer moved many people.
Sinking to the front line of research,Provide insights.The expert team actively participates in various epidemic research and judgments,Has submitted more than 20 significant research reports,Many suggestions have been adopted and applied.
Where is the most nervous,Where is the most dangerous,Wherever there are numerous members of the expert group fighting.
Pathological research is the most basic, most direct and effective way to uncover the truth about new infectious diseases.However, in the early days of the establishment of Vulcan Mountain Hospital,Since there is no existing necropsy room,Pathology research work was once in trouble.
Researcher Qi Jiancheng of the expert group led a team to take the initiative,Creatively put forward the overall plan of using surgical shelter to transform pathological shelter.
They made military orders,In just 5 days,Complete the emergency transformation of the existing conventional surgical shelter.
“Dare to watch,But I have to watch it.”Zhang Zongxing, an engineer who was ordered to the Huoshenshan Hospital, had guaranteed 3 consecutive pathological autopsies for at most one day.He is wearing a three-level protective suit,Worked for more than 11 hours without eating or drinking,The moment he took off his protective clothing,The person is almost collapsed.
The day of order,Forget about home!At the moment,Forget about his dear!When drumming,Forget about it!
Fighting on the front line of the epidemic,There are also three female doctors, Chi Xiangyang, Zhang Mengyao, and Dong Yunzhu-they both participated in the nucleic acid test,Participated in research on vaccines and antibodies.
In more than 100 days in Wuhan,They are used to such overwork,I am used to finding a place to “squint” in a nearby meeting room,Get used to “just touch the bed”,Used to getting acne, dark circles, hair loss on the face.
Because I often miss meals,The masters in the cafeteria are also used to serving them individually in bowls of noodles.once,While waiting for the noodles for a few minutes,Zhang Mengyao was so tired that she fell asleep at the dinner table.
Associate researcher Dong Yunzhu and her husband received a marriage certificate in early 2018.For reasons such as going to Africa to perform medical rescue missions,The wedding date has been postponed twice.She originally planned to hold the wedding in April this year,It had to be postponed for the third time.
Recombinant new crown vaccine (adenovirus vector) approved for clinical trials Shao Longfei Photo
Academician Chen Wei and vaccine clinical trial volunteers together Zhang Zhenwei Photo
Step on the accelerator to the end,All the way forward,Because “In addition to victory,No choice”
March 2,President Xi pointed out when inspecting the Academy of Military Medicine of the Academy of Military Sciences:Give full play to the role of the commando and the main force,Develop safe and effective vaccines, drugs, and testing reagents as soon as possible,Fully meet the needs of fighting the epidemic.
“vaccine,Must first be independently developed by China!”Academician Chen Wei kept in mind the leader’s request,Words are full of confidence.
In late January,The team immediately launched the in-depth bioinformatics analysis and vaccine design of adenovirus vector vaccines.And quickly received special emergency support from the Ministry of Science and Technology.
In Wuhan,Academician Chen Wei is responsible for vaccine research and development,The rear is led by researcher Hou Lihua,Joint local units to coordinate research.
Aim at the target,”Throttle” stepped on to the end,All the way forward.
History will remember this series of flashing moments-
February 26,Vaccine GLP safety evaluation, animal effectiveness evaluation and national third-party quality review were officially launched,Experiments show thatThe vaccine process is stable,The quality meets the expected standard,Good immunogenicity.
March 16,The vaccine passed the clinical research registration review,And completed the first immunization at 20:18 on the same day,Become the world’s first new coronavirus vaccine to conduct clinical trials.
April 10,108 volunteers who completed the Phase I clinical trial of the vaccine,All end concentrated medical observation,Good health.
April 12,The vaccine started phase II clinical trials.This was the only new coronavirus vaccine in the world that entered Phase II clinical trials at that time.
May 22,Phase I clinical results were published in the internationally renowned medical journal “The Lancet”,All 108 volunteers developed an immune response.This is the human clinical data of the world’s first new crown vaccine,It is a milestone in the fight against the new coronavirus.
June 22,The team of Academician Chen Wei discovered the first highly effective neutralizing monoclonal antibody targeting the N-terminal domain of the spike protein.This is after successfully developing the world’s first new crown vaccine,Another major scientific research progress of the team.
July 20,The team of Academician Chen Wei released the Phase II clinical data for the first time to the world.Once again proved the effectiveness and safety of the vaccine,
August 11,The new crown vaccine developed by the team of Academician Chen Wei has obtained the national invention patent.
“We have independent intellectual property rights for this vaccine,It means that we don’t need to look at the faces of others to develop our vaccines at any time and on any occasion.When the subsequent vaccine is put into production and application,We can also let the Chinese people at a lower price when they need it,Get vaccinated the first time.”Chen Wei’s words are sonorous and powerful.
Behind the world’s leading vaccine research and development,Condensed a lot of hard work and dedication of the academician Chen Wei team.
In the later stage of Wuhan’s fight against the epidemic,one day,When Academician Chen Wei went to get a haircut,The barber said distressedly: “Academician,Why do you have so much white hair!”
The academician who had never been gray-haired before discovered thatIn just three months,I gave birth to many gray hairs,People also lost a lot of weight.But she said: “I’ve lost my head for the people of Wuhan,I am willing!”
now,The members of the expert group after returning to the establishment have all returned to their jobs.
Academician Chen Wei and his comrades have already started a new round of “battle”: to accelerate the advancement of the Phase III international multi-center clinical trial of the new crown vaccine,Step up the development of monoclonal antibody drugs specifically for the treatment of new coronavirus infections and new biological drugs to improve the degree of pulmonary fibrosis in patients with new coronary pneumonia,Innovative research and development of new biological protective equipment.
If a person’s career choice can be combined with the country’s major needs,Personal value will be multiplied.This is a saying often said by Academician Chen Wei, winner of the national honorary title of “People’s Hero”.
Inspired and led by Academician Chen Wei,All members of the military medical expert group amplify their value time and time again-
because,In terms of the country, the people, and even mankind,In addition to victory,No choice! (Huang Zijuan, Zhuang Yingna, Wang Di, Wang Jingyi)